Acivir Cream 5%

Acivir Cream 5% (Acyclovir Cream 5%)

Patient Information Guide

Overview

Acivir Cream 5% contains Acyclovir 5%, a topical antiviral medicine used to treat certain skin infections caused by the herpes simplex virus (HSV). It is commonly prescribed to help manage recurrent cold sores (herpes labialis) on the lips and face and, in some situations, other localized herpes simplex skin infections when recommended by a healthcare professional.

Acyclovir does not cure herpes infections or eliminate the virus from the body. Instead, it works by slowing viral replication, which may help reduce the duration and severity of symptoms when treatment is started as early as possible, ideally at the first sign of tingling, itching, or burning.

This medicine is intended for external use only.

Active Ingredient

• Acyclovir 5% w/w

• Drug Class: Antiviral

• Dosage Form: Topical Cream

• Route of Administration: External use

Treatment Objective

To help reduce the duration and severity of localized herpes simplex skin infections when used as directed by a healthcare professional.

How Acivir Cream 5% Works (Mechanism of Action)

Acyclovir enters virus-infected cells and is converted into its active form by viral enzymes. The active medicine blocks viral DNA synthesis by inhibiting viral DNA polymerase.

As a result:

• Viral multiplication slows

• New virus particles are reduced

• Healing may occur more quickly

• Viral spread to nearby skin may be limited

Because it acts primarily in infected cells, healthy skin cells are largely unaffected.

Common Uses

A healthcare professional may recommend Acivir Cream 5% for:

• Recurrent cold sores (herpes labialis)

• Localized herpes simplex skin infections

• Early-stage herpes lesions

• Recurrent HSV outbreaks on suitable external skin areas

This cream is not intended for:

• Internal use

• Eyes

• Inside the mouth

• Inside the nose

• Genital mucous membranes unless specifically directed by a healthcare professional

Directions for Use

Use exactly as prescribed.

General guidance:

• Wash hands before and after application.

• Clean and dry the affected area.

• Apply a thin layer over the affected skin.

• Begin treatment as soon as early symptoms appear (tingling, itching, or redness).

• Avoid rubbing the affected area aggressively.

• Do not cover with airtight dressings unless instructed.

• Complete the recommended treatment course.

Do not use more frequently than instructed.

Precautions

Before using Acivir Cream 5%, tell your healthcare provider if you:

• Have a weakened immune system

• Are pregnant or breastfeeding

• Have allergies to acyclovir or valacyclovir

• Have severe skin disorders

• Are using other prescription topical medicines

Avoid:

• Contact with eyes

• Applying inside the mouth

• Sharing towels or personal items during active outbreaks

• Touching sores unnecessarily

Wash hands after each application.

Possible Side Effects

Most people tolerate topical acyclovir well.

Common Side Effects

• Mild burning

• Temporary stinging

• Dry skin

• Mild redness

• Itching

• Skin irritation

Less Common Side Effects

• Peeling skin

• Mild rash

• Contact dermatitis

Serious Side Effects

Seek immediate medical attention if you develop:

• Severe allergic reaction

• Facial swelling

• Difficulty breathing

• Severe blistering

• Extensive rash

Drug Interactions

Because Acivir Cream is applied to the skin, significant drug interactions are uncommon.

However, tell your healthcare provider if you use:

• Other antiviral medicines

• Prescription skin creams

• Steroid creams

• Cosmetic skin treatments

• Herbal topical products

Pregnancy and Breastfeeding

If you are pregnant, planning pregnancy, or breastfeeding, discuss treatment with your healthcare professional before using Acivir Cream 5%.

Storage

• Store below the temperature recommended on the packaging.

• Keep tightly closed.

• Protect from excessive heat.

• Do not freeze unless instructed by the manufacturer.

• Keep away from children.

Frequently Asked Questions

1. What is Acivir Cream 5% used for?

It is used to treat certain localized herpes simplex virus skin infections, including recurrent cold sores.

2. Does Acivir cure herpes?

No. It helps control symptoms but does not eliminate the virus from the body.

3. When should I start using it?

Treatment is generally most effective when started at the earliest signs of an outbreak.

4. Can I use it inside my mouth?

No. It is intended for external skin use unless otherwise directed by a healthcare professional.

5. Can I use it in my eyes?

No. Avoid contact with the eyes.

6. Is it an antibiotic?

No. It is an antiviral medicine.

7. Can children use Acivir Cream?

Only if recommended by a qualified healthcare professional.

8. Can I wear makeup over the cream?

It is generally best to avoid cosmetics directly over active lesions unless advised otherwise.

9. Can I stop treatment once the sore improves?

Follow the treatment duration recommended by your healthcare professional.

10. Does it prevent future outbreaks?

No. It treats active outbreaks but does not prevent future recurrences.

11. Can I share my cream with someone else?

No. Prescription medicines should never be shared.

12. What if I miss an application?

Apply it when remembered unless it is nearly time for the next application.

13. Can I use it with sunscreen?

Ask your healthcare provider if both products need to be applied to the same area.

14. Can I use it every day?

Use only for the prescribed treatment period unless instructed otherwise.

15. What should I do if irritation becomes severe?

Stop using the cream and contact your healthcare provider.

16. Is it safe for older adults?

It is generally used similarly in older adults, but treatment decisions should be individualized.

17. Can it treat shingles?

Treatment for shingles should be determined by a healthcare professional. Topical acyclovir is not routinely used as first-line treatment for shingles.

18. How should I apply the cream?

Apply a thin layer to clean, dry affected skin using clean hands or a cotton applicator if advised.

19. Can cold sores spread?

Yes. Avoid close contact, kissing, and sharing personal items while sores are active.

20. When should I seek medical advice?

If symptoms worsen, fail to improve, become widespread, involve the eyes, or occur in someone with a weakened immune system, seek prompt medical care.

EEAT Editorial Statement

This educational content has been prepared using established pharmacology references, manufacturer prescribing information, and recognized clinical guidance. It is reviewed for accuracy, clarity, and patient readability. Our goal is to provide balanced, evidence-based health information that supports informed discussions between patients and qualified healthcare professionals.

Medical Disclaimer

This page is provided for educational purposes only and should not replace professional medical advice, diagnosis, or treatment. Acivir Cream 5% should be used only as directed by a qualified healthcare professional or according to approved product labeling. Always consult your physician, pharmacist, or other licensed healthcare provider before starting, stopping, or changing any medication. Seek immediate medical attention if you experience signs of a serious allergic reaction or if symptoms worsen or involve the eyes.